Protective Action of Tinospora Cordifolia Extract against Radiation Induced Biochemical Alterations in Liver

Objective: The present investigation has been carried out to evaluate the possible radio protective potential of Tinospora cordifolia root extract (TCE) against 2.5 Gy gamma radiations induced biochemical alterations in the liver of Swiss albino mice. Methods: For this purpose, healthy Swiss albino male mice were selected from an inbred colony and divided into four groups. Group I (normal) was administered double distilled water (DDW) volume equal to TCE (75mg/ kg.b.wt/ animal) by oral gavage. Group II was orally supplemented TCE as 75mg/ kg. b.wt once daily for 5 consecutive days. Group III (irradiated control) received DDW orally equivalent to TCE for 5 days then exposed to 2.5 Gy gamma radiation. Group IV (experimental) was administered TCE as in group II. and exposed to radiation (as in group III).at various postirradiation intervals between 12 hrs and 30 days. Results: The irradiation of mice caused a considerable elevation in glycogen, total proteins, acid phosphatase and LPO along with a significant decrease in alkaline phosphatase, GSH, catalase and SOD activities. On the contrary, oral administration of TCE before irradiation reduced the radiationinduced variations in all such parameters and the recovery and regeneration was faster as compare to irradiated control group. Conclusion: The present investigation indicates that Tinospora cordifolia has the potential to alleviate the radiation mediated adverse effects in liver and it could be exploited as a protector against planned and unplanned radiation exposure . Original Article PROTECTIVE ACTION OF TINOSPORA CORDIFOLIA EXTRACT AGAINST RADIATION INDUCED BIOCHEMICAL ALTERATIONS IN LIVER PRIYANKA SHARMA, PRADEEP K GOYAL* Radiation & Cancer Biology Laboratory Department of Zoology University of Rajasthan Jaipur302004 India Email: [email protected], [email protected] Received: 22 Apr 2014 Revised and Accepted: 18 May 2014